Anti-Inflammatory Activity of Mycobiont Extract of Parmotrema austrosinense (Zahlbr.) Hale in a Zebrafish Model

Thousands of different kinds lichen metabolites are being examined for their biological activities, including anticancer properties. In this context, the present study aims to assess anti-inflammatory activity acetone extract Parmotrema austrosinense mycobiont. A lipid peroxidation assay was performed with extracts P. mycobiont, which further used evaluate its efficacy using a zebrafish model. Furthermore, histopathological also carried out muscle tissues and amplification inflammation marker. The results revealed that compound (i.e., lecanoric acid) in possesses activity. Histopathology studies confirmed decreased numbers neutrophil cells 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced zebrafishes, as by changes fishes’ weight before after sample treatment, prompted TNBS inflammation. demonstrated dose-dependent decrease (LPO) levels zebrafishes. Gene suggested might perform downregulation inflammatory gene marker tumor necrosis factor (TNF)-α gene; confirms should possess As per literature, is one most complete, comprehensive vivo analyses induced (TNBS). Particularly, successfully identified bioactive isolated from austrosinense, exhibited decent